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Here we investigate the allosteric regulation of the mammalian glutamate dehydrogenase GDH and show how the Guanosine triphosphate (GTP) binding establishes allosteric communication with the regulatory coenzyme NADH which then synergistically inhibits the oxidative deamination activity of GDH by stabilizing its closed conformation

This benefit proves particularly valuable for athletes managing chronic joint stress

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Montemiglio (IBPM, National Research Council, Italy) for helpful discussions of the cryo-EM studies